KMID : 0363819920260010116
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Korean Journal of Nuclear Medicine 1992 Volume.26 No. 1 p.116 ~ p.123
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Distribution of 123I, 99mTc-Human Polyclonal Nonspecific IgG and 67Ga-Citrate in Abscess bearing Mice
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Wee Sup Chung/Sang Moo Lim Kwang Sun Woo
Ok Doo Awh/Yong Sup Seo and Jong Doo Lee
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Abstract
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123I has ideal half life of 13 hours, suitable 159 keV gamma energy for imaging, and easy labeling methods. In Korea Cancer Center Hospital, 123I has been produced by MC-50 cyclotron. The purpose of this study is looking for good labeling
condition
of
123I and 99mTc to nonspecific human polyclonal IgG, and comparing these with 67Ga-citrate in the abscess bearing mice. Human polyclonal nonspecific IgG was labeled with 0.2 M phosphate buffer added 123I by chloramine T method. Human polyclonal
nonspecific IgG was labeled with 99mTc-gluconate after activation with ¥â-mercaptoethanol. In the abscess bearing mice, the radioactivity in the abscess was higher in 24 hours than 6 hours after injection. In the abscess, 123I nonspecific IgG had
higher
uptake than 99mTc-IgG or 67Ga-citrate. There was no significant difference in absecess uptake of 123I-IgG among 24, 72, 120 hours abscess age. Further clinical researches with 123I-nonspecific IgG, and other immunoscintigraphies using 123I are
expected.
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KEYWORD
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